Ali Gharavi, MD


Ali Gharavi, M.D. is Professor of Medicine and Chief of the Division of Nephrology at Columbia University College of Physicians and Surgeons. His is also the Director of the Columbia Institute of Genomic Medicine initiative for kidney Diseases.

Dr. Gharavi applies state of the art genomics approaches to resolve the pathogenesis of complex traits and through this work he has identified many genes and loci predisposing to   glomerulonephritis, hypertension, polycystic liver disease and congenital kidney defects.  The ultimate goal of these projects is to reclassify kidney disorders based on their underlying molecular etiology and individualize care for patients with nephropathy. To achieve this goal, he collaborates with many basic and clinical investigators worldwide and has a successful track record of organizing multidisciplinary groups to bring difficult projects to completion.

He is the principal investigator of multiple NIH R01 studies and is also co-Principal Investigator of an NIDDK-sponsored George O’Brien Urology Center (multi-PI with Drs. Mendelsohn and Barasch), aiming to apply a multidisciplinary approach to study the genetic basis of urinary tract defects.  Together with Drs. Hripcsak and Weng, Dr. Gharavi also leads the Columbia eMERGE Project, which aims to study implement the return of genetic testing results in electronic health records.  Dr. Gharavi’s work has broader implications in Precision Medicine research, and he is now studying the optimal indications for genomic technologies for the diagnosis and targeted care of patients with chronic kidney disease (CKD).   Dr. Gharavi’s research program has also served as a vehicle for training of many students, postdoctoral fellows and clinician-scientists, including faculty member who now have independent careers in kidney research.

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